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Read more →Turn your lab's real-world clinical data into accurate, population-specific reference intervals (RI) that reduce misdiagnosis and lower costs.
RefIQ changes the game in reference interval estimation because it tackles the core weaknesses of how clinical “normal ranges” have traditionally been built.
From small, biased samples → to real-world population scale.
From static ranges → to dynamic, context-aware intervals.
In diagnostics, this truth is fundamental. Every individual’s biology, genetics, lifestyle, and environment create unique health signatures. A one-size-fits-all approach risks missing the nuances that matter most for accurate detection and timely care.
By leveraging advanced medical technology, we are able to refine reference intervals, enabling more accurate interpretation of laboratory test results. This precision in reference ranges directly contributes to improved diagnostic accuracy, optimized treatment plans, and enhanced patient care.
In diagnostics, truth is local. To move from reactive to preventive medicine, we must stop comparing individuals to global averages and start understanding their unique biological context.
"RefIQ moves medicine from reactive to preventive by enabling local, evidence-based diagnostics."
Miguel Angel Fernandez, Biostatistic and Computer Science Engineer - Co-founder & CEO
The Challenge: The central challenge in diabetes diagnostics is the persistent gap between technological sophistication and global accessibility. While high-income regions are moving toward non-invasive wearables and AI-driven "Time in Range" metrics that offer a continuous view of metabolic health, much of the world still relies on infrequent, "snapshot" blood tests like the HbA1c or fasting glucose. These traditional methods often miss the early stages of the disease or fail to distinguish between different types of diabetes, such as Type 1 versus LADA, leading to dangerous misdiagnoses. Consequently, the field is currently defined by a race to develop low-cost, needle-free screening tools that can provide accurate, real-time data without the need for expensive laboratory infrastructure..
The Solution: Tailoring diagnostic reference ranges to an individual's specific biology—rather than using rigid "one-size-fits-all" thresholds—significantly reduces healthcare spending by eliminating unnecessary prescriptions and costly over-treatment. By utilizing precise metrics like Time in Range, clinicians can detect the earliest metabolic shifts, allowing for lifestyle interventions that prevent prediabetes from ever progressing to a full diagnosis. Ultimately, this precision-based approach shifts the financial burden away from treating expensive, chronic complications and toward proactive prevention, resulting in a healthier population and a more sustainable medical economy.
Prevention efficiency:
Saving over 10 year projection
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Excel Spreadsheet (.xlsx)
Collect real-world laboratory test results, containing both normal and pathological values. Data can originate from LIS/HIS systems or clinical databases.Each data point includes test identifier, patient ID, timestamp, and measurement unit.
Observed results are modeled as a mixture of two distributions: Non-pathological. Pathological. The goal is to infer the results of the non-pathological distribution from the observed data using an inverse approach. Multiple candidate parametric distributions are considered (e.g., Normal, Log-Normal, Gamma) to best describe the non-pathological component
The algorithm performs mixture decomposition: Computes the probability that each observed value belongs to the non-pathological vs. pathological distribution. Parameters of candidate models are optimized to maximize the likelihood of the observed dataset.
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CEO and Founder
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